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The High Guide Podcast: 136. What Does 5-MeO-DMT Do to Trust?


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What does 5-MeO-DMT do to trust? April Pride reads from week two of her 12-week Trust Series: her first 5-MeO-DMT experience, approached with the intention of exploring where her self-trust broke down, and the brain science behind why distrust can feel like knowing.

Topics include how 5-MeO-DMT differs from N,N-DMT, synthetic versus toad-derived 5-MeO-DMT, what the StepWise protocol is, and how fear conditioning, extinction learning, and estrogen may shape the way we trust.

Additional Resources

Who was Amanda Fielding?

From the Mac to the Mystical Bill - from The Pattern Project

Read the full Trust Series and show notes on Substack: https://aprilpride.substack.com

Psychedelic Salon at Town Hall Seattle - 2026-27 Schedule

Follow April on Substack

Visit aprilpride.com

Hosted by April Pride

IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@aprilpridecreates

YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@aprilpridecreates

Catch the full episode here

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